Illness and Diseases

EBV is a herpesvirus associated with approximately 1% of tumours worldwide. EBV is the epitome of B lymphotropic viruses, but the spectrum of tumours associated with EBV extends to various types of human malignancies and carcinomas. Ubiquitous EBV infection in humans implies that most individuals carry EBV-infected cells. Therefore, mere detection of the virus in […]

Immunohistochemical staining showed that all induced tumors were LCA (leukocyte common antigen) positive, B-cell marker (CD20, CD79a) positive, and T-cell markers (both CD3 and CD45RO) negative. By these morphological and immunohistochemical features, those tumors can be diagnosed as human B-cell lymphomas. Furthermore, Alu-PCR showed that all of tumor tissues contained 221 bp Alu sequence. It […]

DNA was extracted from tumor tissues as described in protocol. Alu PCR was conducted under the following conditions: 95°C predenaturation for 5 min, and then 30 cycles of denaturation at 94°C for 1 min, annealing at 57°C for 1 min and extension at 72°C for 1 min. Primers (sense: 5′-CAC CTG TAA TCC CAG CAG […]

Background Epstein-Barr virus (EBV) has a close association with various types of human lymphomas. Animal models are essential to elucidate the pathogenesis of human EBV-associated lymphomas. The aim of the present study is to evaluate the association between human IgG concentration and EBV-associated lymphoma development in huPBL/SCID mice. Methods Human peripheral blood lymphocytes (hu-PBL) from […]

Design Controlled clinical trial to evaluate the effect of oral magnesium therapy on ocular blood flow and visual field perimetry indices in patients with normotensive glaucoma (NTG). Blood magnesium level measurement, visual field analysis, and color Doppler imaging of the orbital vessels were done before treatment and at 1 month. Participants Fifteen patients with NTG […]

Hepcidin derived from extrahepatic sources may also exert control over local iron fluxes within tissues in which hepcidin is produced. For example, the central nervous system is separated from the plasma by the blood-brain barrier, and circulating hepcidin may not be transported across this barrier. However, brain tissue itself was reported to express hepcidin, allowing […]

Structurally, the hepcidin peptide resembles a bent hairpin held together by four disulfide bonds. The disulfide connectivity was recently revised. NMR spectroscopy, partial reductive alkylation and Fourier transform mass spectroscopy were used to resolve ambiguities arising from the proximity of the four disulfides. The new model indicates that two bonds stabilize the antiparallel β-sheet, and […]

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic […]

It is increasingly recognized that programs to prevent MTCT must also consider the health of the mother. Antiretroviral prophylaxis regimens, although they prevent MTCT, do not stop progression of HIV infection in the mother. Studies in Africa have shown a 3–4-fold increase in the risk of death in children, regardless of their HIV infection status, […]

A remaining significant challenge in resource-limited countries is transmission of HIV through breast-feeding. Infected women in such settings have a significant dilemma: breast-feeding, although it provides substantial health and survival benefits to the infant and contraceptive, economic, and social benefits to the mother, is associated with risk of HIV transmission to the infant. Avoidance of […]