Monthly Archives: May 2011

Human-derived IgG level

Background Epstein-Barr virus (EBV) has a close association with various types of human lymphomas. Animal models are essential to elucidate the pathogenesis of human EBV-associated lymphomas. The aim of the present study is to evaluate the association between human IgG concentration and EBV-associated lymphoma development in huPBL/SCID mice. Methods Human peripheral blood lymphocytes (hu-PBL) from […]

May 31, 2011 – 6:26 pm | By Dan Frost | Posted in Other | Comments (0)

Antiviral drugs and antiviral activity assays. Part 2

3.1 Complete nucleotide sequence of Korean ECV5 The Korean ECV 5 genome was sequenced (GenBank accession number HM775882) and its amino acid sequence was deduced. The genome is 7,430 nt in length, excluding the poly(A) tail. The 5′NCR contains 738 nt, followed by an ORF that encodes a viral polyprotein consisting of 2,196 codons, between […]

May 26, 2011 – 10:19 pm | By Dan Frost | Posted in Infections | Comments (0)

Magnesium Citrate Improves Vision in Normotensive Glaucoma

Design Controlled clinical trial to evaluate the effect of oral magnesium therapy on ocular blood flow and visual field perimetry indices in patients with normotensive glaucoma (NTG). Blood magnesium level measurement, visual field analysis, and color Doppler imaging of the orbital vessels were done before treatment and at 1 month. Participants Fifteen patients with NTG […]

May 25, 2011 – 10:56 am | By Dan Frost | Posted in Other | Comments (0)

Antiviral drugs and antiviral activity assays

Assays of antiviral activity and cytotoxicity were evaluated by the modified sulforhodamine B (SRB) assay previously described and recently reported by Choi et al. Ribavirin was purchased from DUCHEFA (Netherlands); azidothymidine, acyclovir, amantadine, and lamivudine were purchased from Sigma-Aldrich (St. Louis, MO, USA), as was SRB. One day before infection, Vero cells were seeded onto […]

May 17, 2011 – 3:15 pm | By Dan Frost | Posted in Infections | Comments (0)

Genetic diversity of a Korean echovirus 5 isolate. Part 2

At present, some 40 antiviral drugs have been formally licensed for use in humans, mostly for treatment of human immunodeficiency virus, hepatitis B virus, and herpesvirus infections. The number of antiviral drugs that have been licensed for use in treating highly-pathogenic RNA virus infections is very limited; the current list of approved drugs includes anti-influenza […]

May 13, 2011 – 9:18 pm | By Dan Frost | Posted in Infections | Comments (0)

Genetic diversity of a Korean echovirus 5 isolate

Abstract An outbreak of echovirus 5 (ECV 5) occurred in Korea in 2006, marking the first time this virus had been identified in the country since enterovirus surveillance began in 1993. Using a sample isolated from a young male patient with aseptic meningitis, we performed sequencing of the Korean ECV 5 strain and compared it […]

May 6, 2011 – 11:10 pm | By Dan Frost | Posted in Infections | Comments (0)