Monthly Archives: March 2011

Viagra Canadian Pharmacy: On the Triad Disease, Illness and Sickness

ABSTRACT The point of departure for this article is a review of the discussion between Twaddle and Nordenfelt on the concepts of disease, illness, and sickness, and the objective is to investigate the fruitfulness of these concepts. It is argued that disease, illness, and sickness represent different perspectives on human ailment and that they can […]

March 31, 2011 – 3:44 pm | By Dan Frost | Posted in Diseases | Tagged , | Comments (0)

Mechanism of Hepcidin Action

Hepcidin derived from extrahepatic sources may also exert control over local iron fluxes within tissues in which hepcidin is produced. For example, the central nervous system is separated from the plasma by the blood-brain barrier, and circulating hepcidin may not be transported across this barrier. However, brain tissue itself was reported to express hepcidin, allowing […]

March 26, 2011 – 4:55 pm | By Dan Frost | Posted in Other | Comments (0)

The Role of Hepcidin in Iron Metabolism. Part 2

Structurally, the hepcidin peptide resembles a bent hairpin held together by four disulfide bonds. The disulfide connectivity was recently revised. NMR spectroscopy, partial reductive alkylation and Fourier transform mass spectroscopy were used to resolve ambiguities arising from the proximity of the four disulfides. The new model indicates that two bonds stabilize the antiparallel β-sheet, and […]

March 25, 2011 – 5:23 pm | By Dan Frost | Posted in Other | Comments (0)

The Role of Hepcidin in Iron Metabolism

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic […]

March 23, 2011 – 6:26 pm | By Dan Frost | Posted in Other | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 5

The emergence of SI T cell-line tropic variants in longterm infected individuals progressing to AIDS is well established. This overt replication of SI clones is thought to be due to an increasing qualitative immune deficiency with ongoing infection. Remarkably, in the three individuals with SI isolates described here, these isolates could be detected from the […]

March 20, 2011 – 2:45 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 4

The number of clinical symptoms correlated significantly with both the duration and peak values ofCD8+ lymphocytosis (P < .05 for both comparisons in the Spearman nonparametric rank correlation test). CD8+ T cell numbers were moderately elevated in 5 of II cohort participants and within a normal range in the 6 others (data not shown). Although […]

March 18, 2011 – 9:58 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 3

Virologic analysis. In patients 1-7 seroconversion occurred 11-27 days after the onset ofsymptoms. In patient 8, despite early treatment with zidovudine, seroconversion occurred 41 days after exposure to HIV-I-infected blood. Transient HIV-l antigenemia before seroconversion was detected in seven of eight patients. In patients 1-5 only NSI isolates were recovered. In patients 6 and 8 […]

March 15, 2011 – 9:35 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection. Part 2

The source of infection was unknown for 16 subjects. The virus donor could be identified for the accidentally infected subject 8, for subject 2, a monogamous heterosexual individual with a confirmed seropositive Zairean partner as single-risk factor, and for 1 of the 11 cohort participants, subject 17, a monogamous homosexual man. For subject 17, the […]

March 11, 2011 – 6:04 pm | By Dan Frost | Posted in Infections | Comments (0)

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection

Nineteen individuals were studied for virologic and immunologic events during primary human immunodeficiency virus type 1 (HIV-l) infection. In 16 individuals only non-syncytium-inducing (NSI) isolates were detected; syncytium-inducing (SI) isolates were obtained from 3. Studies of transmitter-recipient pairs indicated that both NSI variants and SI variants were transmitted and that SI variants may be suppressed […]

March 10, 2011 – 9:47 pm | By Dan Frost | Posted in Infections | Comments (0)

Chronic Disease Association

When S. aureus and group A streptococci are thought of, typically boils and pharyngitis, respectively, come to mind rather than the severe infectious diseases that these organisms can cause. Thus, the lack of great attention to these organisms may have allowed them, unchecked, to cause a myriad of chronic diseases that are recognized but whose […]

March 9, 2011 – 6:42 pm | By Dan Frost | Posted in Diseases | Comments (0)